WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=4; E=0.25; R=15.98; rawP=0.0001; adjP=0.0009
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104852 NA SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 6625 ENSG00000104852
2  ENSG00000101161 NA PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) 24148 ENSG00000101161
3  ENSG00000132792 NA CTNNBL1 catenin, beta like 1 56259 ENSG00000132792
4  ENSG00000105618 NA PRPF31 PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) 26121 ENSG00000105618


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=8; E=2.23; R=3.59; rawP=0.0018; adjP=0.0081
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000102978 NA POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 5432 ENSG00000102978
2  ENSG00000130717 NA UCK1 uridine-cytidine kinase 1 83549 ENSG00000130717
3  ENSG00000149809 NA TM7SF2 transmembrane 7 superfamily member 2 7108 ENSG00000149809
4  ENSG00000221988 NA PPT2 palmitoyl-protein thioesterase 2 9374 ENSG00000221988 ENSG00000258388
5  ENSG00000204084 NA INPP5B inositol polyphosphate-5-phosphatase, 75kDa 3633 ENSG00000204084
6  ENSG00000103502 NA CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 10423 ENSG00000103502
7  ENSG00000160408 NA ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 30815 ENSG00000160408
8  ENSG00000174886 NA NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 126328 ENSG00000174886


Database:KEGG pathway       Name:Inositol phosphate metabolism       ID:00562
C=57; O=2; E=0.11; R=17.80; rawP=0.0057; adjP=0.0171
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204084 NA INPP5B inositol polyphosphate-5-phosphatase, 75kDa 3633 ENSG00000204084
2  ENSG00000103502 NA CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 10423 ENSG00000103502


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=2; E=0.13; R=14.92; rawP=0.0080; adjP=0.0180
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000118046 NA STK11 serine/threonine kinase 11 6794 ENSG00000118046
2  ENSG00000204231 NA RXRB retinoid X receptor, beta 6257 ENSG00000204231


Database:KEGG pathway       Name:Phosphatidylinositol signaling system       ID:04070
C=78; O=2; E=0.15; R=13.01; rawP=0.0105; adjP=0.0189
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204084 NA INPP5B inositol polyphosphate-5-phosphatase, 75kDa 3633 ENSG00000204084
2  ENSG00000103502 NA CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 10423 ENSG00000103502


Database:KEGG pathway       Name:Pyrimidine metabolism       ID:00240
C=99; O=2; E=0.20; R=10.25; rawP=0.0165; adjP=0.0248
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000102978 NA POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 5432 ENSG00000102978
2  ENSG00000130717 NA UCK1 uridine-cytidine kinase 1 83549 ENSG00000130717


Database:KEGG pathway       Name:Huntington's disease       ID:05016
C=183; O=2; E=0.36; R=5.55; rawP=0.0508; adjP=0.0653
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000102978 NA POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 5432 ENSG00000102978
2  ENSG00000174886 NA NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 126328 ENSG00000174886


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=2; E=0.42; R=4.76; rawP=0.0664; adjP=0.0747
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000172830 NA SSH3 slingshot homolog 3 (Drosophila) 54961 ENSG00000172830
2  ENSG00000175866 NA BAIAP2 BAI1-associated protein 2 10458 ENSG00000175866


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=2; E=0.64; R=3.11; rawP=0.1355; adjP=0.1355
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
2  ENSG00000204231 NA RXRB retinoid X receptor, beta 6257 ENSG00000204231




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).